Immunology Introductory Textbook ~ Revised Second Edition

Immunology Introductory Textbook ~ Revised Second Edition
by: Nandini Shetty.


Copyright 2005 New Age International (P) Ltd., Publishers
Published by New Age International (P) Ltd., Publishers


PREFACE TO THE SECOND EDITION
As textbooks and journals of immunology grow in size and number and the explosion of
information floods the libraries, students often find themselves overwhelmed by the volume of
reading required to understand basic concepts. Assimilating a fast changing, ever expanding
subject like immunology can be a daunting process. As a teacher of immunology and clinical
microbiology for undergraduate medical students, I have tried to present the basic tenets of the
subject of immunology in a simple and understandable manner, very much like the many
lectures I have given to students over the years. I have tried to evolve a story so that students
may be inspired to read on and experience the wonder of scientific discovery. To this end I owe
my own enjoyment of the subject to the many excellent articles in Scientific American Medicine,
to the pictorial presentation of immunological concepts in Ivan Roitts excellent textbooks of
Immunology and to Basic and Clinical Immunology of the Lange Medical Publication series. I
gratefully acknowledge these sources for the many ideas and figures that I have adapted for
this book. The second edition has been carefully updated, with some chapters being rewritten
incorporating several new illustrations, in keeping with scientific advances. A new chapter
dedicated to the immunology of HIV has been added in recognition of the devastating pandemic
that has re-defined global health. I hope the book will be of use to students of medicine,
microbiology, nursing and for any one else in the life sciences who feels the need to explore this
fascinating area of science.
London Nandini Shetty






CONTENTS
Preface to the Second Edition........................................... ......................................... vii
Preface to the First Edition .................................................. ...................................... ix
List of Abbreviations .................................................. ................................................. xi
1. Milestones in Immunology .................................................. ........................................ 1
2. Innate Immunity .................................................. .................................................. ...... 5
3. Immunobiology..................................... .................................................. .................... 12
4. Antigens and Immunogenicity .................................................. ................................ 20
5. Immunoglobulins I: Structure and Function .................................................. .......... 25
6. Immunoglobulins II: The Genetics of Antibody Diversity ........................................ 33
7. The Complement System .................................................. ........................................ 39
8. Detection and Application of Antigen-Antibody Reactions ....................................... 50
9. Monoclonal Antibodies .................................................. ............................................. 70
10. The Major Histocompatibility Complex .................................................. .................. 75
11. Immune Response Mechanismis I: B and T Lymphocytes....................................... 87
12. Immune Response Mechanismis II: Antigen Presentation and
Processing; Mechanisms of Lymphocyte Activation ................................................ 97
13. Cytokines .................................................. .................................................. ...............107
14. Cell-Mediated Immunity .................................................. .........................................117
15. Hypersensitivity .................................................. .................................................. ....126
16. Immunologic Tolerance and Autoimmunity .................................................. ..........143
17. Immunopotentiation and Immunosuppression .................................................. .....144
18 Transplantation Immunology .................................................. .................................158
19. Tumour Immunology .................................................. ..............................................166
20. Immunity Against Infectious Diseases .................................................. ...................174
21. Immunization .................................................. .................................................. ........180
22. Immunodeficiency Diseases .................................................. ...................................186
23. Immunology of HIV Infection .................................................. .................................197
24. Immunity and Malnutrition .................................................. ...................................200
Index .................................................. .................................................. ......................203

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